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Updated: Jan 8, 2026

Trace Fear Conditioning in Mice
Published on: March 20, 2014
Axon initial segment dynamics during associative fear learning
Chloé Maëlle Benoit1,2, Dan Alin Ganea3,4, Ricardo Paricio-Montesinos1
1Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
None:
The axon initial segment (AIS) is the site of action potential generation and exhibits structural and functional plasticity upon adaptation of neuronal excitability and disease. Performing in vivo longitudinal two-photon imaging of AIS in the medial prefrontal cortex of male mice, we reveal dynamic AIS remodeling during associative fear learning and extinction. These results demonstrate that AIS plasticity is not only crucial for homeostatic adaptation but also a hallmark of memory formation.
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