Comparative Analysis of Collagen Induction in Sprague Dawley Rat Model Using Absorbable Threads for Facial Lifting...

Area of Science:

• Biomaterials Science
• Dermatology
• Tissue Engineering

Background:

• Facial aging necessitates effective and biocompatible rejuvenation methods.
• Absorbable threads offer a minimally invasive approach to facial lifting and skin tightening.
• Understanding the biological response to different absorbable threads is crucial for optimizing aesthetic outcomes.

Purpose of the Study:

• To evaluate the efficacy and biocompatibility of six different absorbable threads for facial lifting.
• To assess collagen production, inflammatory responses, and skin remodeling induced by these threads.
• To provide a basis for developing improved thread-lifting products.

Main Methods:

• Six types of absorbable threads (PCL, PDO, PDLLA, PLCL, P4HB variants) were implanted in Sprague Dawley rats.
• Histological, immunohistochemical, and molecular analyses were performed at 1, 2, 4, and 8 weeks post-insertion.
• Inflammatory markers (TNF-α, IL-6), collagen levels (Collagen 1), gene expression, and protein levels (TGF-β, α-SMA) were quantified.

Main Results:

• All absorbable threads demonstrated a safe profile, with inflammatory markers peaking at 1 week and subsiding by 8 weeks.
• Significant collagen type 1 production was observed from 2 to 8 weeks, alongside reduced metalloproteinase expression, indicating collagen stability.
• Increased expression of collagen-related genes and elevated TGF-β and α-SMA levels suggested enhanced skin remodeling capabilities.

Conclusions:

• All tested absorbable threads effectively promote collagen formation and exhibit minimal, transient inflammatory responses.
• These findings validate the use of absorbable threads for facial rejuvenation, leading to improved skin elasticity and firmness.
• The study provides valuable insights for the future development of advanced thread-lifting technologies.