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Evaluation of systemic inflammatory biomarkers associated with high-density lipoprotein in keratoconus patients: a

Burçin Çakır1, Muhammed Muaz Osmanoğlu2, Büşra Güner Sönmezoğlu3

  • 1Department of Ophthalmology, Sakarya Training and Research Hospital, Sakarya, Turkey. burcincakir@sakarya.edu.tr.

BMC Ophthalmology
|December 24, 2025
PubMed

Insights

Platelet to HDL ratio (PHR) is elevated in keratoconus (KC) patients. This study found no correlation between systemic inflammatory markers and corneal topography in KC.

Area of Science:

  • Ophthalmology
  • Immunology
  • Biochemistry

Background:

  • Keratoconus (KC) is a progressive corneal ectasia.
  • Systemic inflammation may play a role in KC pathogenesis.
  • HDL-associated inflammatory markers require further investigation in KC.

Purpose of the Study:

  • To evaluate systemic inflammatory markers, including monocyte to HDL ratio (MHR), neutrophil to HDL ratio (NHR), lymphocyte to HDL ratio (LHR), neutrophil to lymphocyte ratio (NLR), and platelet to HDL ratio (PHR), in KC patients.
  • To investigate correlations between these markers and corneal topographic parameters.

Main Methods:

  • Retrospective analysis of peripheral blood samples from 103 KC patients and 99 controls.
  • Calculation of mean MHR, NHR, LHR, NLR, and PHR.
  • Evaluation of corneal topography markers and their correlation with systemic inflammatory markers.

Main Results:

  • The mean platelet to HDL ratio (PHR) was significantly higher in the KC group compared to controls (p=0.004).
  • An optimal PHR cut-off value of 4807 was identified for KC, with 74.8% sensitivity and 45.5% specificity.
  • No significant correlations were found between corneal topography parameters and systemic inflammatory markers.

Conclusions:

  • Mean PHR is elevated in keratoconus patients.
  • No correlation exists between HDL-associated systemic inflammatory markers and corneal topography in KC.
  • This study is the first to explore HDL-associated systemic inflammatory markers in keratoconus.
Abstract

Keywords:
High density lipoproteinPlateletProgressive keratoconusSystemic inflammation

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