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Minor Cannabinoid Use Among Medical Cannabis Patients.

Carrie Cuttler1, Kevin F Boehnke2,3, Mitchell L Doucette4

  • 1Department of Psychology, Washington State University, Pullman, WA, USA.

Journal of Psychoactive Drugs
|December 24, 2025
PubMed
Summary

Medical cannabis patients frequently use emerging cannabinoids like cannabidiol (CBD) and delta-8 tetrahydrocannabinol (delta-8 THC) for medical conditions and well-being. Many substitute cannabis for other medications, highlighting the need for public health education on these novel products.

Keywords:
CBGCBNMinor cannabinoidsdelta-8-THCemerging cannabinoidsmedical cannabis patients

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Area of Science:

  • Pharmacology
  • Cannabinoid Science
  • Public Health

Background:

  • US cannabis legalization has increased access to novel cannabinoids.
  • Limited understanding exists regarding the use of emerging cannabinoids by medical cannabis patients.

Purpose of the Study:

  • To characterize the usage patterns (frequency, administration methods) and motivations for using emerging cannabinoids among US medical cannabis patients.
  • To assess the extent to which medical cannabis patients substitute emerging cannabinoids for traditional medications.

Main Methods:

  • A survey was administered to a large sample (N=1721) of US-based medical cannabis patients.
  • Data collected included patterns of use, administration methods, and reasons for using a wide variety of emerging cannabinoids.

Main Results:

  • Cannabidiol (CBD), delta-9-THC, delta-8-THC, and THCA were the most frequently used cannabinoids in the past year, with daily use common.
  • Smoking flower, vape pens/cartridges, and edibles were the primary administration methods for most cannabinoids.
  • Patients primarily used cannabis for medical conditions, well-being, and as a medication substitute, with a majority reporting cessation of pharmaceuticals/other drugs.

Conclusions:

  • Emerging cannabinoid products are substantially used by a large cohort of medical cannabis patients.
  • Significant public health outreach and education are necessary to inform individuals about these novel cannabinoid products and their use.