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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Basic Science and Pathogenesis.

Chirag Sharma1

  • 1MMCP, Ambala, Haryana, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Targeting the NLRP3 inflammasome offers a new approach to Alzheimer's disease (AD) prevention and treatment. Understanding its role in neuroinflammation and protein aggregation is key to developing novel therapeutic strategies for AD.

Keywords:
AD(Alzheimer's disease)ChemokinesCytokinesNLRP3 inflammasomeTau proteininterleukinsleucine neurodegenerative diseases.

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Area of Science:

  • Neuroscience
  • Immunology

Background:

  • Neurodegenerative diseases, including Alzheimer's disease (AD), are increasing with aging populations.
  • Hallmarks include protein aggregation, metabolic issues, immune system imbalance, and neuron loss.

Purpose of the Study:

  • To explore the role of the NLRP3 inflammasome in Alzheimer's disease pathogenesis.
  • To identify potential therapeutic targets for AD based on NLRP3 inflammasome modulation.

Main Methods:

  • Investigated the NLRP3 inflammasome as a pattern recognition receptor in innate immunity.
  • Examined NLRP3 inflammasome activation triggers like reactive oxygen species, lysosomal damage, and mitochondrial DNA.
  • Reviewed literature on NLRP3's role in cytokine/chemokine production (IL-1β, IL-18) and its link to tau and Aβ deposition in AD.

Main Results:

  • Recent advancements in AD prevention and treatment highlight the NLRP3 inflammasome.
  • Key mechanisms influencing AD pathogenesis, such as autophagy and cytokine release, impact NLRP3 inflammasome activation.

Conclusions:

  • Targeting NLRP3 inflammasome activation/inactivation offers a novel perspective on AD pathophysiology.
  • Modulating the NLRP3 inflammasome presents a potential new strategy for AD prevention and treatment.