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Related Concept Videos

Targeted Cancer Therapies02:57

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Related Experiment Video

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
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Protocol for Chinese lung cancer evolution and microenvironment tracking under therapy study.

Wenxiang Wang1,2,3, Yue He1,2,3, Xiaoqiu Yuan3

  • 1Thoracic Oncology Institute, Peking University People's Hospital, Beijing, China.

Journal of Translational Internal Medicine
|December 24, 2025
PubMed
Summary

The Chinese Lung Cancer Evolution and Microenvironment Tracking under Therapy (CLEVER) study investigates lung cancer heterogeneity. This research aims to decode molecular evolution and personalize treatments for better patient outcomes.

Keywords:
cancer evolutionlung cancertumor heterogeneity

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Area of Science:

  • Oncology
  • Genomics
  • Cancer Evolution

Background:

  • Lung cancer research often overlooks tumor heterogeneity by analyzing single regions.
  • Existing studies, like TRACERx, focused on Western populations, leaving gaps in understanding Asian lung cancer.
  • Tumor evolution and microenvironment interactions are critical but underexplored in Chinese lung cancer.

Purpose of the Study:

  • To decipher the molecular evolution of Chinese lung cancer using multi-region tumor sampling.
  • To analyze the impact of tumor evolution and neoadjuvant therapy on the tumor microenvironment.
  • To identify biomarkers for treatment effectiveness and recurrence in Chinese lung cancer patients.

Main Methods:

  • Established the prospective Chinese Lung Cancer Evolution and Microenvironment Tracking under Therapy (CLEVER) study cohort.
  • Acquired comprehensive genetic variation data and clonal events from multiple tumor regions.
  • Utilized personalized minimal residual disease (MRD) panels for mutation monitoring and tracing evolutionary significance.

Main Results:

  • Comprehensive genetic variation and clonal data acquired from multi-region Chinese lung cancer samples.
  • Characterization of tumor microenvironment remodeling due to evolution and neoadjuvant therapy.
  • Identification of potential markers influencing treatment response and recurrence.

Conclusions:

  • The CLEVER study provides insights into the molecular evolution of Chinese lung cancer.
  • Understanding tumor heterogeneity and microenvironment is key to improving treatment strategies.
  • Personalized minimal residual disease monitoring aids in therapy decision-making and patient outcomes.