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Updated: Jan 21, 2026

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
06:51

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

Published on: November 14, 2025

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Dual-modality theranostics probes: sintegrative strategies for precision management of oncologic malignancies

Xilin Jing1,2,3, Yutao Li1,2,3, Yijing Zhang4

  • 1Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, China.

Life Medicine
|January 20, 2026
PubMed

Insights

Theranostics, integrating imaging and therapy, offers precision oncology through dual-modality probes. Further research into probe design and cancer-specific selection is crucial for clinical advancement.

Area of Science:

  • Oncology
  • Medical Imaging
  • Nanotechnology

Background:

  • Cancer presents a significant global health burden.
  • Immunotherapy and targeted therapies have transformed cancer care.
  • Theranostics merges molecular imaging and therapy for precision oncology.

Purpose of the Study:

  • To review the design principles and clinical applications of dual-modality probes in theranostics.
  • To identify challenges and propose strategies for enhancing the translational potential of these probes.

Main Methods:

  • Systematic evaluation of dual-modality probes.
  • Analysis of positron emission tomography, fluorescence, and magnetic resonance imaging technologies.
  • Review of current research and early clinical trials.

Main Results:

  • Dual-modality probes offer synergistic advantages like complementary imaging and real-time monitoring.
  • Challenges include biosafety, metabolic stability, and imaging resolution.
  • Structural optimization and cancer-subtype-specific selection are key.

Conclusions:

  • Dual-modality probes are vital for advancing precision oncology.
  • Addressing current limitations is essential for successful clinical translation.
  • Further development is needed to fully realize the potential of theranostic probes.
Keywords:
dual-modality probesmolecular imagingprecision oncologytheranostics

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