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Updated: Jan 8, 2026

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Native-carboxylate-assisted enantioselective C-H annulations with allenes and 1,3-dienes on ferrocene
Devendra Parganiha1, Yagya Dutt Upadhyay1, Sumit Khevariya1
1Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal By-Pass Road, Bhopal, Madhya Pradesh 462066, India. sangitkumar@iiserb.ac.in.
Abstract:
Native carboxylate as a directing group in enantioselective C-H activation results in poor stereodiscrimination, due to dynamic ligand exchange during the enantiodetermining concerted metalation-deprotonation (CMD) step. Herein, we present the synthesis of a new class of chiral ferrocene-fused isochroman derivatives from the readily available native carboxylate functionality. The Pd(II)/MPAA-derived enantioselective C-H activation and intermolecular annulation with allenes and 1,3-dienes afforded structurally diverse ferrocene-fused isochromans with up to 80% yield and 96 : 4 enantioselectivity.
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