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Updated: Jan 8, 2026
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Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
Published on: June 14, 2020
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Basic Science and Pathogenesis
Avishek Roy1, Filipa Monteiro Rocha1, Mukesh Varshney1
1Karolinska Institutet, Stockholm, Sweden.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
Summary
This study reveals significant reactive astrogliosis in Parkinson's disease (PD) brains, highlighting astrocytic ICAM1 as a key factor. Novel PET tracers offer potential for visualizing glial activation in PD.
Area of Science:
- Neuroscience
- Immunology
- Radiochemistry
Background:
- Glial cell activation (astrocytes and microglia) is implicated in Parkinson's disease (PD) neuroinflammation.
- Lack of specific biomarkers hinders tracking glial activation in PD.
- Novel positron emission tomography (PET) tracers for glial cells show promise but require further investigation in PD.
Purpose of the Study:
- To investigate glial-mediated inflammation in Parkinson's disease (PD) brains.
- To evaluate novel PET tracers for visualizing reactive astrocytes and activated microglia.
- To elucidate the role of astrogliosis and ICAM1 in PD pathogenesis.
Main Methods:
- Utilized a multi-PET tracer approach with radioligand binding assays.
- Conducted postmortem brain imaging autoradiography studies.
- Performed morphometric and marker analyses for astrocytes and microglia (GFAP, S100B, IBA1).
Main Results:
- 3H-BU99008 and 3H-Deprenyl showed distinct binding sites, potentially targeting different astrocyte subpopulations.
- Significant reactive astrogliosis was observed in PD brains compared to controls.
- Upregulation of GFAP/ICAM1 positive-reactive astrocytes was identified in PD, indicating ICAM1's role in inflammation.
Conclusions:
- This study provides a comprehensive view of reactive astrogliosis in advanced PD.
- Astrocytic ICAM1 plays a significant role in PD pathogenesis.
- Further research will explore the astrocyte-microglia interplay and ICAM1's role in neuroinflammation.
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