Effects of Ozonized Oil on At-Home Tooth Bleaching: A Double-Blind Randomized Clinical Trial

This double-blind, randomized clinical trial evaluated the effect of ozonized sunflower oil on tooth sensitivity, color change, and patient perception during at-home bleaching with 10% hydrogen peroxide.

Forty participants were randomly assigned to receive ozonized or nonozonized sunflower oil, applied in trays for 1 min after each bleaching session (30 min daily for 21 days). Sensitivity was assessed daily using visual and numerical scales. Tooth color was measured at baseline, 1 week, and 1 month after treatment using a spectrophotometer (ΔEab, ΔE00, ΔWID) and a visual shade guide (ΔSGUs). Patient perception was evaluated through Likert-scale questionnaires.

Overall, 72.5% of participants experienced sensitivity, with no significant difference in intensity (p = 0.536) or duration (p = 0.256) between groups. Color changes were similar (p > 0.05), although ΔEab and ΔE00 values decreased at 1 month (p = 0.010 and p = 0.026). Ozonized oil had an unpleasant taste (p = 0.002) and odor (p = 0.010). The use of ozonized sunflower oil did not reduce bleaching-related sensitivity or enhance whitening effectiveness, and its poor sensory properties may limit patient acceptance.