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An Innovative Formula for Keratosis Pilaris Treatment-A Randomized Controlled Study Based on the

Fangzhou Liu¹, Lu Cheng², Jie Yang²

¹Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.

Journal of Cosmetic Dermatology

|December 24, 2025

Summary

A novel combined formula significantly improved keratosis pilaris (KP) by reducing follicular papules and improving skin hydration. This treatment also decreased transepidermal water loss (TEWL) and alleviated associated depressive symptoms in patients.

Keywords:

follicular papules keratosis pilaris papain plant oils scrub

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Area of Science:

Dermatology
Cosmetic Science
Clinical Research

Background:

Keratosis pilaris (KP) is a common follicular disorder causing papules, roughness, and psychological distress.
Existing treatments offer limited efficacy, necessitating novel therapeutic approaches.

Purpose of the Study:

To evaluate the 28-day effectiveness of a novel combined formula for treating keratosis pilaris.
Assessed improvements in follicular papules, skin barrier function, and psychological well-being.

Main Methods:

A 28-day randomized controlled study involving 60 KP patients (aged 18-35).
Participants were assigned to a control group (salicylic acid lotion) or a study group (combined formula: scrub and lotion).
Evaluations included follicular papule counts, transepidermal water loss (TEWL), and depression scale scores.

Main Results:

The combined formula significantly reduced follicular papules and improved skin hydration compared to the control.
A significant decrease in TEWL was observed in the study group, indicating enhanced skin barrier function.
The study group reported higher effectiveness across 21 self-assessment indicators, including skin dryness and smoothness, and showed significant psychological improvement.

Conclusions:

The novel combined formula is effective in managing keratosis pilaris symptoms.
The treatment improves skin hydration, reduces TEWL, and positively impacts patients' psychological health.
This highlights the potential of the combined formula for comprehensive KP management.