Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metformin modifies hormone changes associated with androgen deprivation therapy for prostate cancer.

Endocrine oncology (Bristol, England)·2026
Same author

Germline CDK12 variants in aggressive prostate cancer.

Cancer discovery·2026
Same author

Outcomes of a Canadian real-world cohort of metastatic castration-sensitive prostate cancer patients stratified by early PSA nadir.

Future oncology (London, England)·2026
Same author

Five-year follow-up of the SABR-5 trial: primary toxicity analysis of stereotactic ablative radiotherapy for up to five oligometastases.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Impact of cisplatin dose, renal function, and other factors on audiometrically-assessed ototoxicity in more than 1400 adult-onset cancer survivors from The Platinum Study: a multicentre cohort study.

EClinicalMedicine·2026
Same author

Genetic testing practices among specialist physicians who treat prostate cancer: Updated survey of Canadian practitioners.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada·2026

Related Experiment Video

Updated: May 12, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.1K

Bladder Preservation in Muscle-Invasive Bladder Cancer: A Population-Based Analysis from British Columbia.

Guliz Ozgun1, Abraham Alexander2, Gregory Arbour3

  • 1BC Cancer Vancouver Center, Medical Oncology, Vancouver, BC V5Z 4E6, Canada.

Current Oncology (Toronto, Ont.)
|December 24, 2025
PubMed
Summary

Bladder preservation strategies like trimodal treatment (TMT) show potential for muscle-invasive bladder cancer (MIBC) patients. While not statistically significant in this study, combined chemoradiotherapy offered numerical survival improvements over radiation alone.

Keywords:
MIBCbladder preservationchemoradiationpersonalized medicineradiation

More Related Videos

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
08:15

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Published on: February 11, 2014

16.3K
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.5K

Related Experiment Videos

Last Updated: May 12, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

24.1K
Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
08:15

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts

Published on: February 11, 2014

16.3K
Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.5K

Area of Science:

  • Urology
  • Oncology
  • Radiation Oncology

Background:

  • Muscle-invasive bladder cancer (MIBC) presents significant treatment challenges with standard therapies like radical cystectomy (RC) linked to adverse outcomes.
  • Bladder preservation strategies, including trimodal treatment (TMT), are emerging alternatives for select MIBC patients, yet their adoption in Canada is limited.
  • Real-world data on the efficacy of bladder-sparing radiotherapy for MIBC in Canada is scarce.

Purpose of the Study:

  • To evaluate the real-world outcomes of bladder-sparing radiotherapy in British Columbia.
  • To compare the effectiveness of combined chemoradiotherapy versus radiation therapy alone for MIBC.
  • To identify factors influencing therapeutic outcomes in bladder cancer treatment.

Main Methods:

  • Retrospective evaluation of bladder cancer patients treated with radiotherapy in British Columbia.
  • Comparison of outcomes between patients receiving combined chemoradiotherapy (concurrent/adjuvant/neoadjuvant chemotherapy) and those receiving radiation therapy alone.
  • Analysis of disease-specific survival and progression-free survival as primary endpoints.

Main Results:

  • The cohort treated with combined chemoradiotherapy demonstrated numerical improvements in disease-specific survival and progression-free survival compared to radiation therapy alone.
  • These observed differences did not achieve statistical significance, potentially due to study limitations.
  • The study underscores the importance of patient selection for optimizing treatment outcomes.

Conclusions:

  • Combined chemoradiotherapy shows a trend towards improved outcomes in MIBC compared to radiation alone, though not statistically significant in this cohort.
  • Appropriate patient selection is crucial for successful bladder preservation strategies.
  • Future research should focus on biomarker-driven approaches for personalized treatment selection in MIBC, especially for elderly patients with comorbidities.