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Clinical and Histological Assessment of Knife-Edge Thread Implant Stability After Ridge Preservation Using
Lidija Veljkovic1, Miljana Nedeljkovic1, Gvozden Rosic2
1Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Dentistry Journal
|December 24, 2025
Summary
Alveolar ridge preservation (ARP) using hydroxyapatite and sugar cross-linked collagen (HSCC) with knife-edge thread implants (KTIs) promotes bone regeneration. This novel approach supports successful dental implant placement in sites with bone defects.
Area of Science:
- Dental Implantology
- Regenerative Medicine
- Biomaterials Science
Background:
- Primary dental implant stability relies on bone quality, quantity, and implant design.
- Large bone defects, like periapical lesions, necessitate effective alveolar ridge preservation (ARP) for successful bone regeneration and implant site preparation.
- Evaluating novel ARP materials and implant designs is crucial for optimizing outcomes in compromised bone sites.
Purpose of the Study:
- To assess the clinical and histological results of a new alveolar ridge preservation (ARP) material, hydroxyapatite and sugar cross-linked collagen (HSCC).
- To evaluate the combination of HSCC with a knife-edge thread implant (KTI) design for dental implant placement.
- To compare outcomes between a control group (spontaneous healing with KTI) and an experimental group (ARP with HSCC followed by KTI).
Main Methods:
- Thirty patients were allocated to either a control or experimental group.
- The experimental group received ARP using HSCC, followed by KTI placement after six months.
- Clinical parameters (insertion torque value, implant stability quotient, horizontal bone dimension) and histological analyses were performed for both groups.
Main Results:
- No significant differences were found in insertion torque value, implant stability quotient, or horizontal bone dimension between the groups.
- Histological analysis revealed a significantly higher number of active osteoblasts in the ARP group compared to the control group (p < 0.001).
- Conversely, collagen deposition was significantly greater in the control group (p < 0.001).
Conclusions:
- Alveolar ridge preservation (ARP) using HSCC combined with KTIs creates favorable conditions for primary implant stability.
- This combination facilitates successful graft integration, enabling reliable dental implant placement even in sites with significant bone defects.
- The HSCC material shows promise for enhancing bone regeneration in compromised alveolar ridges.
