Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.1K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.1K
Cancer Prevention02:59

Cancer Prevention

7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

6.0K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
6.0K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.8K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.8K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biocontrol of Mycotoxin-Producing Fungi by Lactic Acid Bacteria.

Foods (Basel, Switzerland)·2026
Same author

The Role of Artificial Intelligence in the Characterization and Outcome Prediction of Prostate Cancer: A Systematic Review.

Tomography (Ann Arbor, Mich.)·2026
Same author

Long-Term Thyroid Complications Post-COVID-19: A Systematic Review.

Microorganisms·2026
Same author

The Diet-Microbiota-Polyamine Axis in Intestinal Aging: Microbial Pathways, Functional Foods, and Physiological Implications.

Nutrients·2026
Same author

Anti-diabetic drugs: a novel therapeutic approach against cisplatin-induced kidney injury, a mechanistic review of preclinical studies.

Journal of diabetes and metabolic disorders·2026
Same author

Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.

Journal of xenobiotics·2026

Related Experiment Video

Updated: Jan 7, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.5K

Bisphenol A (BPA) Modifies Cancer Signaling Pathways: A Neglected Global Health Threat.

Minatullah Al-Ani1, Yassir Al-Ani2, Shahad Sabaawi Ibrahim1

  • 1Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.

Journal of Xenobiotics
|December 24, 2025
PubMed
Summary

Bisphenol A (BPA) exposure is linked to cancer development by affecting cell signaling pathways. BPA-free alternatives like BPS and BPF may also pose health risks, necessitating safer substitutes and regulations.

Keywords:
Bisphenol ABisphenol AFBisphenol FBisphenol SGPER pathwaycancer signaling pathwaysendocrine disrupting chemicalsestrogen receptor pathway

More Related Videos

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.4K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

15.2K

Related Experiment Videos

Last Updated: Jan 7, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.5K
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays
08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.4K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

15.2K

Area of Science:

  • Environmental Health
  • Toxicology
  • Cancer Biology

Background:

  • Bisphenol A (BPA) is a widespread industrial chemical found in plastics.
  • Human exposure to BPA is increasing, raising concerns about its carcinogenic potential.
  • BPA accumulates in tissues and can exert harmful effects despite lower estrogen receptor affinity.

Purpose of the Study:

  • To review current evidence on Bisphenol A's role in cancer initiation and progression.
  • To focus on BPA's impact on cancer signaling pathways.
  • To discuss exposure routes and the implications of BPA alternatives.

Main Methods:

  • Literature review of existing studies on Bisphenol A and cancer.
  • Analysis of BPA's effects on cellular pathways regulating growth, movement, invasion, survival, and adhesion.
  • Examination of exposure pathways, primarily dietary intake from packaged foods.

Main Results:

  • BPA acts as an estrogen ligand, activating estrogen receptor pathways.
  • It modulates key signaling pathways involved in cancer development.
  • Migration of BPA from packaging increases with temperature, enhancing exposure.
  • BPA alternatives like BPS and BPF may present similar or greater health risks.

Conclusions:

  • BPA significantly influences cancer signaling pathways, contributing to initiation and progression.
  • Dietary exposure is a primary concern, exacerbated by temperature-dependent migration.
  • The use of BPA alternatives like BPS and BPF requires careful evaluation due to potential health risks.
  • Further research is needed for safe substitutes, removal technologies, and regulatory measures.