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Area of Science:

  • Microbiology and Human Physiology
  • Aging Research
  • Nutritional Science

Background:

  • Intestinal aging involves declining epithelial renewal, barrier function, and immune balance, linked to gut microbial shifts.
  • Polyamines (putrescine, spermidine, spermine) are crucial microbial-host metabolites supporting intestinal health.
  • Age-related decline in polyamine production contributes to intestinal dysfunction and inflammation.

Purpose of the Study:

  • To explore the diet-microbiota-polyamine axis in intestinal aging.
  • To integrate evidence on dietary components, gut microbes, and polyamine metabolism.
  • To evaluate strategies for enhancing polyamine availability and gut homeostasis.

Main Methods:

  • Narrative review synthesizing experimental, animal, and human evidence.
  • Focus on microbial polyamine metabolism, particularly by lactic acid bacteria.
  • Analysis of mechanistic pathways linking polyamines to intestinal health.

Main Results:

  • Dietary components shape gut microbial ecology and polyamine production.
  • Polyamines are vital for epithelial regeneration, immune modulation, and barrier maintenance.
  • Age-associated dysbiosis disrupts beneficial microbial-host polyamine interactions.

Conclusions:

  • Modulating the diet-microbiota-polyamine axis is a promising strategy for healthy intestinal aging.
  • Nutritional and microbial interventions (fermented foods, prebiotics, probiotics) can enhance polyamine levels.
  • Targeting microbial polyamine production offers translational potential for gut health interventions.