Cryoneurolysis: An Emerging Personalized Treatment Strategy for Significant Pelvic Pain
Shamar Young1, Artyom Abramyan1, Ilaria Vittoria De Martini1
1Division of Interventional Radiology, Department of Medical Imaging, University of Arizona, Tucson, AZ 85724, USA.
Journal of Personalized Medicine
|December 24, 2025
Summary
Cryoneurolysis offers a personalized approach to treating pelvic pain by targeting specific nerves. This technique provides a promising alternative to opioids, addressing the need for novel pain management strategies.
Area of Science:
- Pain Management
- Neurology
- Interventional Procedures
Background:
- Pelvic pain is a common condition in the U.S.
- The opioid epidemic necessitates alternative pain relief strategies.
- Cryoneurolysis is an emerging treatment for pain.
Purpose of the Study:
- To review cryoneurolysis for pelvic pain.
- To discuss mechanism, literature, and technique.
- To explore future directions for this treatment.
Main Methods:
- Literature review of cryoneurolysis.
- Description of cryoneurolysis mechanism.
- Outline of patient workup and technique for pelvic pain targets.
Main Results:
- Cryoneurolysis targets specific peripheral nerves for personalized pain relief.
- The pudendal nerve and impar ganglion are viable targets for pelvic pain.
- This review synthesizes current knowledge on cryoneurolysis for pelvic pain.
Conclusions:
- Cryoneurolysis presents a viable, targeted alternative for pelvic pain management.
- Further research and clinical application are warranted.
- This technique aligns with the need for non-opioid pain treatments.
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