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Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Stage-Specific Molecular Signatures and Prognostic
Lorenza Vantaggiato1, Marco Frisenda2, Enxhi Shaba1
1Functional Proteomics Laboratory, Department of Life Sciences, University of Siena, 53100 Siena, Italy.
Proteomes
|December 24, 2025
Summary
This study identified distinct protein profiles in non-muscle invasive bladder cancer (NMIBC) subtypes. Key proteins like PDC6I/ALIX were downregulated in aggressive tumors, suggesting new prognostic biomarkers for personalized NMIBC management.
Area of Science:
- Oncology
- Proteomics
- Molecular Biology
Background:
- Non-muscle invasive bladder cancer (NMIBC) has high-grade (HG) and low-grade (LG) variants.
- Current diagnosis relies on cystoscopy, lacking less-invasive alternatives.
- Molecular drivers of NMIBC tumorigenesis and treatment response remain unclear.
Purpose of the Study:
- To identify molecular differences between pTa-LG and pT1-HG NMIBC.
- To discover potential prognostic biomarkers for NMIBC.
- To explore proteomic distinctions for personalized treatment.
Main Methods:
- Preliminary top-down proteomic analysis of fresh NMIBC biopsies.
- Comparison of protein profiles between pTa-LG and pT1-HG stages at initial diagnosis.
Main Results:
- Distinct protein profiles were observed between pTa-LG and pT1-HG NMIBC.
- Proteins involved in apoptosis regulation (e.g., PDC6I/ALIX) were downregulated in pT1-HG.
- Proteins like GANAB, GALE, and SEPT8 correlated with tumor size, indicating prognostic potential.
Conclusions:
- Identified proteins may serve as valuable prognostic markers for NMIBC.
- These findings could enable more personalized NMIBC management strategies.
- Proteomic analysis offers insights beyond traditional diagnostic approaches.
