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Curcumin-Loaded Nanoscale Metal-Organic Frameworks for Therapeutic Applications in Cancer
Helda Tutunchi1,2, Hafezeh Nabipour2, Sohrab Rohani2
1Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz 51666-14711, Iran.
Nanomaterials (Basel, Switzerland)
|December 24, 2025
Summary
Metal-Organic Frameworks (MOFs) show promise in cancer research by improving curcumin
Area of Science:
- Nanotechnology in Oncology
- Materials Science for Drug Delivery
- Natural Product Chemistry
Background:
- Curcumin exhibits potent anti-inflammatory, antioxidant, and anticancer properties.
- Clinical application of curcumin is hindered by poor solubility, rapid degradation, and low bioavailability.
- Combining curcumin with other agents can enhance stability and antitumor activity.
Purpose of the Study:
- To review the potential of Metal-Organic Frameworks (MOFs) as nanocarriers for curcumin.
- To highlight how MOFs can overcome curcumin's limitations.
- To explore MOFs' role in improving cancer therapy.
Main Methods:
- Literature review on MOFs and curcumin in cancer research.
- Analysis of MOF properties relevant to drug delivery.
- Evaluation of studies demonstrating enhanced curcumin stability and efficacy using MOFs.
Main Results:
- MOFs offer a porous, tunable platform for encapsulating curcumin.
- MOF encapsulation significantly improves curcumin's stability and bioavailability.
- MOFs facilitate controlled or sustained release of curcumin, enhancing therapeutic outcomes.
Conclusions:
- Metal-Organic Frameworks (MOFs) are highly promising nanocarriers for curcumin in cancer therapy.
- MOFs enhance curcumin's stability, bioavailability, and targeted delivery.
- Further research into MOF-curcumin systems could lead to improved cancer treatments.
