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Related Experiment Video

Updated: Jan 7, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

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Published on: March 30, 2020

Curcumin-Based Supplement for Vitreous Floaters Post-Nd:YAG Capsulotomy: A Pilot Study.

Alex Malandrini¹, Giovanni Rubegni¹, Davide Marini¹

¹Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.

Vision (Basel, Switzerland)

|December 24, 2025

Summary

This study found that a dietary supplement significantly reduced symptomatic vitreous floaters (SVFs) and foreign body sensations after Nd:YAG laser capsulotomy. The supplement, containing specific nutrients, improved vision quality and was well-tolerated by patients.

Keywords:

Nd:YAG laser bromelain curcumin vitreous constituents vitreous floaters

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Area of Science:

Ophthalmology
Nutritional Science
Medical Devices

Background:

Symptomatic vitreous floaters (SVFs) can occur after Nd:YAG laser capsulotomy.
Evaluating non-invasive treatments for post-procedural SVFs is crucial.

Purpose of the Study:

To assess the short-term efficacy of a dietary supplement on SVFs post-Nd:YAG laser capsulotomy.
To evaluate the supplement's impact on visual function and patient-reported outcomes.

Main Methods:

A randomized controlled trial with 40 participants experiencing SVFs.
Treatment group received oral supplement plus standard therapy; control group received standard therapy only.
Outcomes measured included visual acuity, contrast sensitivity, subjective questionnaires, and novel ultrasound-based vitreous evaluations (MVP, MGI).

Main Results:

The treatment group showed significant improvements in contrast sensitivity, floater perception, daily activity interference, foreign body sensation, MVP, and MGI compared to the control group.
Best-corrected visual acuity remained comparable between groups.
The dietary supplement was well-tolerated.

Conclusions:

Short-term oral supplementation with vitreous-specific nutrients effectively reduces SVFs and associated symptoms after Nd:YAG capsulotomy.
This nutritional approach may offer a promising non-invasive therapeutic option for managing post-Nd:YAG capsulotomy SVFs.