Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computational Advances in Biomaterial Engineering: Mapping Research Trajectories Through Bibliometric Analysis.

Tissue engineering. Part B, Reviews·2026
Same author

Creation of an Ex Vivo Liver Human Model for Microwave Ablation Investigation.

Journal of vascular and interventional radiology : JVIR·2026
Same author

Alzheimer's Imaging Consortium.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Spatial Dissociation of Atrophy and Hypophysiology in Alzheimer's Disease: Implications for Biomarkers.

Human brain mapping·2025
Same author

Changes in Microwave Ablation Zone Dimensions after Transarterial Embolization in an Ex Vivo Human Kidney Perfusion Model.

Journal of vascular and interventional radiology : JVIR·2024
Same author

Evaluation of the Catheter Clamp over Hydrophilic Guide Wire Central Venous Catheter Exchange Technique for Air Embolism Prophylaxis in an In Vitro Model.

Journal of vascular and interventional radiology : JVIR·2023
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Annie Dang1, Di Wang1, Mohamad Habes2

  • 1UT Health San Antonio, San Antonio, TX, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) shows distinct patterns of brain atrophy and hypometabolism, impacting different cognitive functions. Separating these biomarkers is crucial for accurate AD diagnosis and treatment strategies.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Neurology
  • Biomarker Discovery

Background:

  • Alzheimer's disease (AD) diagnosis historically noted distinct patterns of brain hypometabolism and atrophy.
  • The A/T/N framework has grouped these distinct biomarkers, potentially losing critical diagnostic nuance.
  • Recent iterations of the A/T/N framework aim to incorporate more detailed biomarker profiling.

Purpose of the Study:

  • To conduct a large-scale meta-analysis characterizing the dissociation between hypometabolism and atrophy in AD.
  • To compare the behavioral associations linked to distinct atrophy and hypometabolism patterns.
  • To explore network-level connections influenced by these differing neuropathological processes.

Main Methods:

  • Utilized BrainMap databases for voxel-based morphometry (VBM) for atrophy and voxel-based physiology (VBP) for hypometabolism meta-analyses.
  • Performed activation likelihood estimation on 412 VBM and 462 VBP contrasts to identify convergent brain alteration patterns.
  • Employed meta-analytic connectivity modeling, using VBM/VBP regions as nodes, to explore network-level functional connectivity.

Main Results:

  • VBM analysis revealed atrophy predominantly in the bilateral hippocampus, temporal gyrus, and insula.
  • VBP analysis identified hypometabolism primarily in the posterior cingulate and bilateral parietal lobes.
  • Distinct behavioral associations were observed: atrophy linked to memory/emotion, hypometabolism to reasoning/memory/social cognition.

Conclusions:

  • Atrophy and hypometabolism in AD exhibit distinct spatial patterns and are associated with different behavioral changes.
  • This dissociation suggests potentially distinct underlying neuropathologies for atrophy and hypometabolism.
  • Advocates for the separate inclusion of atrophy and hypometabolism as distinct biomarker categories in AD profiling.