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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Related Experiment Video

Updated: Jan 7, 2026

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
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Integrated Multi-Omic Analysis Identifies Altered Colonic Brush Border Profile as a Key Feature of Microscopic

Danila Guagnozzi1,2,3,4, Ana Maria Gonzalez-Castro1,2,4, Yamile Zabana4,5

  • 1Laboratory of Neuro-immuno-gastroenterology, Vall d'Hebron Institut de Recerca, Barcelona, Spain.

United European Gastroenterology Journal
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Microscopic colitis (MC) involves altered colonic epithelial cells, affecting brush border structure and protein expression. These findings offer new insights into MC pathogenesis and potential diagnostic biomarkers.

Keywords:
brush bordercollagenous colitislymphocytic colitismicroscopic colitismicrovilli

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Area of Science:

  • Gastroenterology
  • Cell Biology
  • Inflammatory Bowel Disease Research

Background:

  • Microscopic colitis (MC), including lymphocytic colitis (LC) and collagenous colitis (CC), is a growing inflammatory bowel disease.
  • Its exact cause is unknown, but compromised colonic epithelial barrier function may allow antigen exposure, triggering inflammation.

Purpose of the Study:

  • To investigate the role of the colonic epithelium in microscopic colitis.
  • To compare epithelial changes in LC and CC patients with controls.

Main Methods:

  • Paired transcriptomic and proteomic analyses of colonic biopsies from LC, CC, IBS-D, and healthy subjects.
  • Epithelial ultrastructural examination and evaluation of budesonide therapy effects on CC epithelial structure.

Main Results:

  • MC patients showed altered expression of proteins involved in cell adhesion and actin cytoskeleton organization.
  • Collagenous colitis (CC) exhibited shorter, fewer microvilli, with partial improvement after budesonide; lymphocytic colitis (LC) had reduced microvilli number.
  • A negative correlation was observed between stool frequency and SPATN1/ATP8B1 protein levels in CC.

Conclusions:

  • The colonic epithelium in LC and CC displays molecular dysregulation and abnormal brush border ultrastructure.
  • These findings enhance understanding of MC pathogenesis and suggest potential biomarkers for diagnosis and treatment.