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Sandhya Mangalore¹

¹National Institute of Mental Health and Neurosciences, Bengaluru, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 24, 2025

Summary

This summary is machine-generated.

Perfusion imaging using pseudo-continuous arterial spin labeling (pCASL) shows reduced cerebral blood flow (CBF) in temporal and parietal lobes of Alzheimer's disease (AD) patients. This highlights pCASL's potential for diagnosing AD and understanding neurodegeneration.

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Area of Science:

Neuroimaging
Cerebrovascular Physiology
Neurodegenerative Diseases

Background:

Cerebral blood flow (CBF) is crucial for understanding Alzheimer's disease (AD) pathophysiology.
Perfusion imaging, specifically pseudo-continuous arterial spin labeling (pCASL), offers a non-invasive method to measure CBF.

Purpose of the Study:

To evaluate the diagnostic potential of pCASL in patients with Alzheimer's disease.
To correlate pCASL findings with known patterns of neurodegeneration in AD.

Main Methods:

A prospective, cross-sectional observational study included 25 patients diagnosed with AD.
pCASL MRI was performed as part of the patients' MRI examinations.
Cerebral parcellation was conducted using Cortex_ID for detailed analysis.

Main Results:

Hypo-perfusion on pCASL MRI was predominantly observed in the temporal and parietal lobes, mirroring brain parenchymal atrophy.
Significant hypo-perfusion was noted in the posterior cingulate gyrus (bilaterally), precuneus, and superior/inferior parietal lobes.
These findings align with established patterns of AD-related neurodegeneration.

Conclusions:

pCASL demonstrates significant potential for the diagnosis of Alzheimer's disease.
The study confirms prevalent hypo-perfusion in temporal and parietal lobes, consistent with DMN disruption and AD pathology.
Standardized pCASL protocols and multimodal approaches are recommended for robust biomarker development and early AD diagnosis.