Jove
Visualize
Contact Us

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

The enigma of reflex eating epilepsy: A cohort study of 50 patients with insights from multimodal evaluation.

Epileptic disorders : international epilepsy journal with videotape·2025
Same author

Production of [<sup>18</sup>F]NAV4694 on an FX2N synthesis module for imaging amyloid plaques.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2025
Same author

A Comparative Analysis of Different MRI Sequences Dedicated for Invivo Detection of Mineralization in a Single Large Cohort of Progressive Supranuclear Palsy and Healthy Controls.

Neurology India·2025
Same author

Multiplex connectomics reveal altered networks in frontotemporal dementia: A multisite study.

Network neuroscience (Cambridge, Mass.)·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Sandhya Mangalore1

  • 1National Institute of Mental Health and Neurosciences, Bengaluru, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Echo planar MR Spectroscopy (EPSI) reveals metabolic changes in Alzheimer's disease (AD) patients, showing decreased N-acetylaspartate and increased lactate. This aids in early AD diagnosis and monitoring treatment effectiveness.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroimaging
  • Metabolic Neuroscience
  • Biomarker Discovery

Background:

  • Echo planar MR Spectroscopy (EPSI) is a key technique for investigating metabolic alterations in Alzheimer's Disease (AD).
  • Understanding these metabolic shifts is crucial for developing diagnostic and prognostic tools for AD.

Purpose of the Study:

  • To assess brain metabolite distribution and concentration in AD patients using EPSI MRI.
  • To correlate metabolic findings with atrophy patterns and FDG-PET data.
  • To evaluate the utility of EPSI in early AD detection and treatment monitoring.

Main Methods:

  • A prospective, cross-sectional observational study involving 25 AD patients and 10 healthy controls.
  • EPSI MRI was performed to measure brain metabolite levels (NAA, Cho, Cr, Glx, Lac, mI).
  • Findings were correlated with MRI-derived atrophy patterns and FDG-PET imaging.

Main Results:

  • Significant decreases in N-acetylaspartate (NAA) and Choline (Cho) were observed in multiple brain regions of AD patients.
  • Elevated lactate (Lac) levels were found in the left parietal inferior lobe and right posterior cingulate gyrus.
  • Altered metabolite ratios (e.g., NAA/Cr, Glx/Cr) and increased Myo-inositol (mI) suggest neuronal dysfunction and glial activation.

Conclusions:

  • EPSI imaging, when integrated with MRI and FDG-PET, offers a comprehensive metabolic profile of AD.
  • The observed metabolic alterations support EPSI's role in early AD diagnosis and therapeutic intervention monitoring.
  • EPSI's ability to register with MP-RAGE allows for multi-planar reconstruction, enhancing its diagnostic value.