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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Christopher E Bauer1, Colleen Pappas1, Brian T Gold1,2

  • 1University of Kentucky, Lexington, KY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Neurodegenerative proteinopathies are linked to changes in medial temporal lobe (MTL) brain volumes and white matter tracts. This study found that cumulative proteinopathy scores correlated with altered diffusion properties in MTL tracts, particularly the cingulum of the hippocampus.

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Area of Science:

  • Neuroimaging
  • Neuropathology
  • Gerontology

Background:

  • Neurodegenerative proteinopathies, such as Alzheimer's disease, are linked to medial temporal lobe (MTL) volume loss.
  • The impact of these proteinopathies on MTL white matter tracts is less understood.

Purpose of the Study:

  • To investigate the association between neuropathologically confirmed proteinopathies and antemortem MRI-derived white matter diffusion properties in MTL tracts.

Main Methods:

  • Utilized post-mortem brain tissue and antemortem MRI scans from 51 older adults.
  • Assessed Alzheimer's disease, TDP-43, and Lewy Body pathology, calculating a cumulative proteinopathy score.
  • Analyzed fractional anisotropy (FA) in major MTL white matter tracts (cingulum, uncinate fasciculus, IFOF, fornix) and regional volumes.

Main Results:

  • A significant main effect of cumulative proteinopathy score was observed on both MTL structure volumes and white matter tract FA values.
  • Post-hoc analysis indicated this effect was significant for the cingulum of the hippocampus (p < 0.001).
  • The association between proteinopathy and cingulum FA remained significant even after controlling for hippocampal and amygdala volumes.

Conclusions:

  • Aggregated proteinopathies are associated with alterations in both MTL volumes and white matter tracts.
  • Further research is required to determine if diffusion metric changes precede volumetric changes in the MTL.