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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
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Full-color imaging with a 3D nanoprinted fiber endoscope
Optics Letters
|December 24, 2025
Summary
Researchers developed a miniaturized fiber endoscope using 3D nanoprinting. This advanced technology corrects optical aberrations for high-quality, full-color imaging in medical and industrial applications.
Area of Science:
- Optics and Photonics
- Nanotechnology
- Medical Imaging
Background:
- Microsized full-color endoscopes are crucial for minimally invasive diagnostics and industrial inspections.
- Fabrication and optical aberration correction present significant challenges for miniaturized endoscopes.
Purpose of the Study:
- To propose and demonstrate a miniaturized fiber endoscope with enhanced optical performance.
- To overcome fabrication and aberration correction challenges in microendoscope development.
Main Methods:
- Utilized two-photon polymerization (TPP) 3D nanoprinting technology.
- Integrated multiple freeform microlenses onto an imaging fiber tip.
- Employed advanced fabrication for aberration correction and full-color imaging.
Main Results:
- Achieved a field of view (FOV) of 60° and a resolution of 7.13 line pairs per mm (lp/mm).
- Successfully corrected optical aberrations, enabling high-quality full-color imaging.
- Demonstrated accurate color reproduction and preservation of image details.
Conclusions:
- The proposed fiber endoscope offers an innovative solution for high-performance microendoscope development.
- TPP 3D nanoprinting enables effective aberration correction and miniaturization.
- The technology enhances imaging capabilities for medical and industrial applications.

