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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Cécile Tissot1, Feng Han2, Ji Yeon Lee1

  • 1Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Meningeal signal variability differs between tau-PET tracers, with [18F]MK6240 linked to glymphatic clearance in females and age in males. [18F]FTP signal is mainly age-dependent in both sexes.

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Area of Science:

  • Neuroimaging
  • Molecular Imaging
  • Brain Physiology

Background:

  • Meningeal signal variability observed with tau-PET tracers.
  • Sex and age influence tracer uptake.
  • Role of glymphatic clearance in variability is unclear.

Purpose of the Study:

  • Compare meningeal signal of [18F]MK6240 and [18F]FTP tau-PET tracers.
  • Investigate associations with age, sex, and glymphatic clearance.
  • Examine cognitively unimpaired, amyloid-beta-negative individuals.

Main Methods:

  • 92 cognitively unimpaired individuals underwent [18F]MK6240 and [18F]FTP tau-PET scans.
  • Meningeal regions defined across nine levels.
  • Glymphatic clearance measured via gBOLD/CSF coupling; analyzed with t-tests and linear regression.

Main Results:

  • [18F]MK6240 and [18F]FTP meningeal signals correlated in both sexes.
  • [18F]MK6240 signal higher in females; [18F]FTP showed no sex difference.
  • Female [18F]MK6240 signal linked to glymphatic clearance; male [18F]MK6240 and both sexes' [18F]FTP linked to age.

Conclusions:

  • [18F]MK6240 meningeal signal associates with glymphatic clearance in females and age in males.
  • [18F]FTP meningeal signal primarily influenced by age in both sexes.
  • Highlights distinct tracer-PET relationships with glymphatic function and aging.