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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Alejandra García-Colomo1

  • 1Centro de Neurociencia Cognitiva y Computacional, Madrid, Spain; Center for Cognitive and Computational Neuroscience, Madrid, Madrid, Spain; Universidad Complutense de Madrid, Madrid, Madrid, Spain.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Early Alzheimer's disease (AD) detection is possible using electrophysiology. Changes in brain activity, like altered centrality and spectral power, correlate with biomarkers such as p-tau231 and vascular damage in cognitively unimpaired and MCI individuals.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Alzheimer's Disease Research

Background:

  • Alzheimer's disease (AD) is increasingly understood as a biological continuum, necessitating early detection for intervention.
  • Electrophysiological measures are crucial for identifying functional alterations from the earliest pathological stages.
  • This study investigates electrophysiological changes linked to AD biomarkers in early disease stages.

Purpose of the Study:

  • To explore electrophysiological alterations in cognitively unimpaired (CU) and mild cognitive impairment (MCI) individuals.
  • To associate these alterations with biomarkers like plasma p-tau231, NfL, and white matter hyperintensities.
  • To understand the functional impact of these biomarkers on brain networks.

Main Methods:

  • Magnetoencephalography (MEG) resting-state scans were performed on 404 CU individuals and 117 MCI patients.
  • Associations between plasma p-tau231, NfL levels, and brain source centrality were evaluated.
  • Relationships between white matter hyperintensities and spectral power were assessed.

Main Results:

  • Increased plasma p-tau231 in CU individuals correlated with altered theta and gamma centrality, affecting brain hubs.
  • Vascular damage in CU and MCI individuals was linked to reduced beta relative power, indicating compromised structural integrity.
  • Electrophysiological findings suggest early neuronal dysfunction and vascular impairment.

Conclusions:

  • Observed centrality alterations support early hub vulnerability in AD due to amyloid-beta deposition and neuronal dysfunction.
  • Spectral signatures of vascular impairment align with existing literature.
  • Further research is needed to standardize definitions and replicate findings for vascular impairment in AD.