A daily-durable wearable sweat biosensing device with robust reticular conductive biogel interface

Area of Science:

• Biomedical Engineering
• Materials Science
• Analytical Chemistry

Background:

• Wearable biosensors are crucial for at-home chronic disease management.
• Clinical translation is limited by poor durability and stability of existing biosensors.
• Long-term, real-world use requires robust and stable sensing technologies.

Purpose of the Study:

• To develop a daily-durable wearable electrochemical biosensor array.
• To enable continuous analysis of sweat glucose and lactate.
• To overcome limitations of current biosensors in real-world applications.

Main Methods:

• Encapsulating ZIF-90@enzymes within a conductive gel matrix.
• Creating a robust reticular biogel interface for sweat analysis.
• Integrating the biosensor array with a paper-based sweat collector and PCB.

Main Results:

• The biosensor array demonstrated exceptional durability and environmental adaptability.
• Sensitivity remained >95% after 10h outdoor exposure and >85% after 1000 bends.
• Excellent pH/temperature tolerance and 140-day room-temperature storage stability were achieved.

Conclusions:

• The developed wearable biosensor offers a promising solution for routine health monitoring.
• Its robustness and stability support continuous on-body sweat analysis.
• The device shows significant potential for managing chronic diseases through accessible health tracking.