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Updated: Jan 7, 2026
Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
Published on: November 22, 2019
Ultra-sensitive radio-frequency biosensor based on mode-locked fiber laser using functionalized tilted fiber Bragg
Mengzhu Zhang1, Jiafeng Shan2, Zhijuan FuYang1
1State Key Laboratory of Opto-Electronic Information Acquisition and Protection Technology, School of Physics and Optoelectronics Engineering, Anhui University, Hefei, 230039, China; The Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University, Hefei, 230039, China; Key Laboratory of Opto-Electronic Information Acquisition and Manipulation, Ministry of Education, Anhui University, Hefei, 230039, China.
This study introduces an ultra-sensitive radio-frequency (RF) biosensor for detecting low-abundance biomarkers. The novel device achieves high sensitivity and specificity, paving the way for advanced clinical diagnostics and personalized medicine.
Area of Science:
- Biomedical Engineering
- Optoelectronics
- Biosensing Technology
Background:
- Conventional biomarker detection methods lack sensitivity and specificity, especially with high background interference.
- Accurate detection of low-abundance biomarkers is critical for clinical diagnostics and personalized medicine.
Purpose of the Study:
- To develop an ultra-sensitive radio-frequency (RF) biosensor for enhanced biomarker detection.
- To integrate mode-locked fiber laser technology with a functionalized tilted fiber Bragg grating (TFBG) for real-time biomolecular analysis.
Main Methods:
- Fabrication of a TFBG using femtosecond laser writing and functionalization with protein-A.
- Integration of the TFBG into a mode-locked fiber laser cavity for simultaneous mode-locking and sensing.
- Real-time biomolecular detection via measurement of laser repetition rate shifts caused by anti-CK17 binding.
Main Results:
- Achieved ultra-sensitive detection of anti-CK17 with a limit of 10^-12 g/mL.
- Demonstrated quantification across eight orders of magnitude with high specificity.
- Exhibited a sensitivity of 40.95 Hz/decade.
Conclusions:
- The integrated mode-locked laser and TFBG biosensor offers a robust platform for high-performance biomarker detection.
- This technology holds significant potential for real-time biomedical diagnostics and rapid disease marker analysis.
- The developed biosensor overcomes limitations of conventional techniques, enabling sensitive detection under challenging conditions.
