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Rethinking First-Line Therapy and Beyond: HER2-Positive and Hormone Receptor-Positive/HER2-Negative Metastatic Breast

Wolfgang Janni1, Rebecca A Dent2, Peter Schmid3

  • 1Department of Obstetrics and Gynecology, Ulm University Hospital, Universitätsfrauenklinik Ulm, Ulm, Germany.

Clinical Breast Cancer
|December 24, 2025
PubMed

Keywords:
Antibody-drug conjugate (ADC)Biomarker-guided therapyHER2-positive breast cancerHormone receptor–positive breast cancerOral selective estrogen receptor degrader (SERD)

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