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Structural diversity of aldehydes determines covalent versus non-covalent inhibition mechanisms against steroid

Junying Chen1, Shufang Qi1, Zijian Lin1

  • 1Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China; Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China; Key Laboratory of Precision Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China; Key Laboratory of Environment and Male Reproductive Medicine of Wenzhou, Wenzhou, Zhejiang, 325000, China.

Chemico-Biological Interactions
|December 24, 2025
PubMed

Keywords:
5α-reductase type 1AldehydesCovalent inhibitionNon-covalent inhibitionStructure-activity relationship

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