Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of slice thickness on computed tomography perfusion-derived ischemic core volume accuracy in acute ischemic stroke.

Quantitative imaging in medicine and surgery·2026
Same author

Deep-learning reconstruction for noncontrast head computed tomography: Improved image quality and potential diagnostic impact in acute ischemic stroke.

Neuroradiology·2026
Same author

<i>APOE4</i>-dependent association between metformin use and Alzheimer's disease-related cortical thickness in older adults with type 2 diabetes.

Journal of Alzheimer's disease : JAD·2026
Same author

Amyloid-related default mode network hyperconnectivity and longitudinal decline in network distinctiveness in preclinical Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

BMI changes from midlife to late life and their relationship with Alzheimer's disease pathologies.

Alzheimer's research & therapy·2026
Same author

Plasma GFAP as a mediator and moderator of Aβ, tau, and neurodegeneration in Alzheimer's disease.

NPJ dementia·2026

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Dahyun Yi1, Min Soo Byun2,3, Gijung Jung1

  • 1Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea, Republic of (South).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary

Plasma neurofilament light chain (NfL) strongly correlates with MRI-based markers of diffuse neurodegeneration in Alzheimer's disease (AD). This suggests NfL is a valuable indicator of widespread axonal injury and neurodegeneration in AD.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Biomarker Research
  • Alzheimer's Disease Diagnostics

Background:

  • Plasma neurofilament light chain (NfL) is a key biomarker for axonal injury and neurodegeneration (N) in Alzheimer's disease (AD).
  • The precise relationship between plasma NfL and neuroimaging markers of neurodegeneration requires further elucidation.
  • This study aims to investigate the associations between plasma NfL and various neuroimaging markers.

Purpose of the Study:

  • To examine the correlation between plasma NfL levels and neuroimaging indicators of neurodegeneration.
  • To determine if plasma NfL is more closely associated with structural or functional neuroimaging markers.
  • To assess the utility of plasma NfL in reflecting diffuse versus focal neurodegeneration in AD.

Main Methods:

  • Analysis of data from 167 older adults within the AD spectrum from the Korean Brain Aging Study for the Early Diagnosis and Prediction of AD (KBASE).
  • Measurement of plasma NfL using the single molecule array (SIMOA) platform.
  • Utilized structural MRI (cortical thickness, hippocampal volume, SPARE-AD scores) and FDG-PET (hypometabolism) for neuroimaging metrics.
  • Employed linear regression models to assess associations and evaluated model performance using Adjusted R-squared, AIC, and BIC.

Main Results:

  • Plasma NfL showed significant associations with both structural and functional neuroimaging markers of neurodegeneration.
  • Reduced cortical thickness and higher SPARE-AD scores (diffuse atrophy) exhibited the strongest correlations with plasma NfL.
  • While hippocampal volume showed a moderate association, FDG-PET markers, particularly PCC hypometabolism, also demonstrated significant links with plasma NfL.
  • MRI markers, especially those indicating diffuse neurodegeneration, displayed stronger and more consistent associations with plasma NfL compared to FDG-PET markers.

Conclusions:

  • Plasma NfL is more strongly associated with MRI-derived markers of diffuse structural neurodegeneration than with FDG-PET markers of functional decline.
  • These findings highlight the importance of considering the interplay between plasma NfL and specific neuroimaging modalities for accurate AD diagnosis and monitoring.
  • Plasma NfL serves as a valuable indicator reflecting widespread neurodegenerative processes in Alzheimer's disease.