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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Dillys Xiaodi Liu1, Clémence Cavaillès1, Meredith N Braskie2

  • 1Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Longer sleep durations and poor sleep quality are linked to worse Alzheimer's Disease (AD) biomarkers in older adults. This study used objective sleep measures and MRI to explore these associations in a diverse population.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Sleep Medicine

Background:

  • Poor sleep is a known risk factor for Alzheimer's Disease (AD).
  • The precise relationship between objective sleep characteristics and AD biomarkers remains unclear.
  • This study investigated sleep patterns and AD-related MRI biomarkers in older adults.

Purpose of the Study:

  • To examine associations between objective sleep metrics and AD-related MRI biomarkers.
  • To understand how sleep duration, efficiency, and fragmentation relate to brain changes in aging populations.
  • To investigate these relationships in a diverse cohort of community-dwelling older adults.

Main Methods:

  • Utilized data from the Dormir Study, part of the Health and Aging Brain Study-Health Disparities (HABS-HD) cohort.
  • Objectively measured sleep using 7-day wrist actigraphy (sleep duration, TIB, SE, WASO, awakening length, fragmentation index).
  • Assessed AD-related MRI biomarkers: hippocampal volume, AD-signature cortical thickness, and white matter hyperintensity (WMH) volume. Employed multivariable linear regressions for analysis.

Main Results:

  • Analyzed data from 703 diverse participants (mean age 66.4 years).
  • Nighttime sleep duration >8 hours, longer total time in bed (TIB), longer wake after sleep onset (WASO), and longer awakening length were associated with smaller hippocampal volume.
  • Nighttime sleep duration >8 hours, longer TIB, and longer awakening length were linked to thinner cortex in AD-signature regions.
  • No significant associations were found between sleep characteristics and white matter hyperintensity (WMH) volume.

Conclusions:

  • Extended nighttime sleep (>8 hours) and indicators of poor sleep quality (longer TIB, WASO, awakening length) correlate with adverse Alzheimer's Disease (AD) related MRI patterns.
  • These findings highlight the importance of sleep in brain health among diverse older adults.
  • Further longitudinal research is recommended to elucidate the underlying pathophysiological mechanisms connecting sleep and AD.