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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jun Sung Kim1, Dahyun Yi2, Min Soo Byun3

  • 1Institute of Human Behavioral Medicine, Seoul National University Medical Reserach Center, Seoul, Seoul, Korea, Republic of (South).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Glial fibrillary acidic protein (GFAP) in blood reflects astrogliosis and influences Alzheimer's disease (AD) progression. GFAP levels mediate and moderate the links between beta-amyloid, tau, and neurodegeneration in AD.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Alzheimer's Disease Research

Background:

  • Glial fibrillary acidic protein (GFAP) is a key marker of astrogliosis in the brain.
  • Astrogliosis is implicated in the neuropathological cascade of Alzheimer's disease (AD).

Purpose of the Study:

  • To investigate if blood GFAP levels mediate or moderate the relationships between core in vivo AD pathologies: beta-amyloid (Aβ) and tau.
  • To explore the association of GFAP with neurodegeneration markers in an aging cohort.

Main Methods:

  • Recruited 92 participants from the Korean Brain Aging Study (KBASE) across a cognitive spectrum.
  • Utilized PET imaging (Aβ, tau, glucose metabolism) and MRI for neuroimaging biomarkers.
  • Measured plasma GFAP and analyzed mediation/moderation effects using PROCESS Macro, adjusting for covariates.

Main Results:

  • Plasma GFAP correlated significantly with Aβ, tau deposition, reduced cerebral glucose metabolism, and hippocampal volume.
  • GFAP mediated the Aβ-tau and tau-glucose metabolism pathways, but not tau-hippocampal volume.
  • GFAP acted as a moderator between Aβ and tau deposition.

Conclusions:

  • Blood GFAP levels serve as a relevant biomarker reflecting astrogliosis in AD.
  • GFAP plays a significant role in mediating and moderating the complex interplay of AD pathologies.