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Updated: Jan 7, 2026
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
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Biomarkers
Elizabeth Divina1, Rani Permata2, Kaven Tannardi1
1Faculty of Medicine, Universitas Indonesia, Central Jakarta, Jakarta, Indonesia.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
Summary
Pentraxin-3 (PTX3) shows a significant negative correlation with cognitive impairment, suggesting its potential as a novel biomarker for cognitive function assessment. Further research is needed due to limited studies.
Area of Science:
- Biomarkers
- Neuroscience
- Vascular Biology
Background:
- Pentraxin-3 (PTX3) is linked to inflammatory processes in vascular pathologies.
- Cognitive impairment often results from vascular events, making PTX3 a relevant marker.
- This study is an updated systematic review and the first meta-analysis on PTX3 and cognitive function.
Purpose of the Study:
- To systematically review and meta-analyze the correlation between Pentraxin-3 (PTX3) and cognitive function.
- To assess the potential of PTX3 as a biomarker for cognitive impairment.
Main Methods:
- Systematic review of five databases and individual searches up to January 2, 2025.
- Inclusion of studies assessing cognitive function in adult patients.
- Meta-analysis of correlation between PTX3 levels and cognitive scores (3MSE, MMSE).
Main Results:
- Eight articles were included, with a total of 6,004 participants (average age 69.08).
- A significant negative correlation was found between PTX3 and cognitive scores (3MSE/MMSE) (r=-0.67; p < 0.001).
- PTX3 was associated with increased cognitive decline and negatively correlated with executive function, with differential effects observed in men and women.
Conclusions:
- Pentraxin-3 (PTX3) demonstrates a significant negative correlation with cognitive impairment, indicating its potential as a novel, less-invasive biomarker.
- The current body of research correlating PTX3 and cognitive function is limited.
- Further research is warranted to fully elucidate the role of PTX3 in cognitive function.
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