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Clinical Manifestations.

Astrid Coleman1, Renée K Biss1, Ana Badal2

  • 1University of Windsor, Windsor, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Subjective cognitive complaints (SCCs) do not consistently predict mild cognitive impairment (MCI) or normal aging. Specific memory complaints differentiate MCI from subjective cognitive decline (SCD) based on birthplace, highlighting cultural influences on cognitive assessment.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychology

Background:

  • Subjective cognitive complaints (SCCs) are crucial for diagnosing mild cognitive impairment (MCI).
  • The diagnostic utility of SCCs in distinguishing MCI from normal aging is unclear.
  • Cultural factors influencing SCCs are often overlooked in research.

Purpose of the Study:

  • To determine if specific SCCs predict MCI or intact cognitive functioning.
  • To investigate whether these predictions differ between individuals born in Canada and abroad.
  • To explore the impact of birthplace on the presentation of cognitive complaints.

Main Methods:

  • Retrospective study of older adults (60-94 years) evaluated at a memory clinic.
  • Participants classified as MCI (n=74) or subjective cognitive decline (SCD; n=60).
  • SCCs assessed using the Multifactorial Memory Questionnaire (MMQ) Abilities subscale; birthplace (Canada vs. abroad) also recorded.

Main Results:

  • Overall SCC frequency did not differ by clinical group or birthplace.
  • Specific SCCs, particularly regarding prospective memory, were more common in Canada-born individuals.
  • SCCs related to semantic memory loss differentiated SCD from MCI in Canada-born individuals but not in those born abroad.

Conclusions:

  • Summary SCC scores lack strong association with objective cognitive function.
  • Certain SCCs vary by birthplace, and specific complaints differentiate clinical groups based on birthplace.
  • Clinical assessment of cognitive decline requires consideration of cultural factors and refined SCC measures for improved utility.