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Clinical Manifestations.

Alexander Ivan B Posis1, Kristen M George1, Hilary L Colbeth1

  • 1University of California, Davis, Davis, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

Cognitive performance varies among Asian American subgroups, with Filipino participants showing lower executive function at baseline. These differences in cognitive function persisted over time, highlighting the need for disaggregated data.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Asian Americans are a heterogeneous group with diverse exposures.
  • Aggregating Asian Americans masks potential cognitive differences.
  • Research is needed to compare cognitive performance across Asian American subgroups.

Purpose of the Study:

  • To compare cognitive performance across diverse Asian American subgroups.
  • To investigate differences in executive function and verbal episodic memory.
  • To examine cognitive change over time in Asian American populations.

Main Methods:

  • 786 Asian American participants from Kaiser Healthy Aging and LifeAfter90 studies.
  • Assessed executive function (EF) and verbal episodic memory (VM) using the Spanish and English Neuropsychological Scales.
  • Used analysis of covariance and linear mixed-effects models, adjusting for age, gender, and education.

Main Results:

  • Significant baseline differences in EF and VM were observed across subgroups.
  • Filipino participants had significantly lower baseline EF scores compared to Japanese participants.
  • No significant differences in cognitive change over time were found for EF or VM.

Conclusions:

  • Disparities in baseline cognitive performance exist among Asian American subgroups.
  • These disparities, particularly in executive function, persisted over time.
  • Disaggregated data is crucial for understanding and reducing cognitive disparities in Asian Americans.