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Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
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DynamicAtlas: a morphodynamic atlas for Drosophila development.

Matthew F Lefebvre1, Vishank Jain-Sharma1, Nikolas Claussen1

  • 1Department of Physics, University of California Santa Barbara, Santa Barbara, CA, USA.

Nature Methods
|December 24, 2025
PubMed
Summary
This summary is machine-generated.

DynamicAtlas reveals distinct developmental stages in fruit fly embryos by analyzing tissue flow patterns. These

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Area of Science:

  • Developmental biology
  • Biophysics
  • Genetics

Background:

  • Organismal shape arises from complex gene-gene and gene-environment interactions.
  • Static atlases offer limited insight into dynamic shape changes during development.
  • Live imaging is crucial for understanding morphogenetic processes.

Purpose of the Study:

  • To develop a comprehensive 'morphodynamic atlas' for analyzing dynamic shape changes in developing organisms.
  • To identify and characterize distinct phases of tissue movement during embryonic development.
  • To investigate the genetic and mechanical factors influencing developmental shape transitions.

Main Methods:

  • Creation of DynamicAtlas, integrating live and static imaging data from 500 Drosophila melanogaster embryos.
  • Alignment of diverse datasets to a common morphological timeline for comparative analysis.
  • Analysis of surface tissue flows to identify 'morphodynamic modules' and their dependence on genetic mutations and environmental factors.

Main Results:

  • Identification of 'morphodynamic modules' in wild-type embryos, corresponding to key developmental stages.
  • Discovery that stationary flow patterns are regulated by genes controlling dorsal-ventral axis symmetry.
  • Demonstration that morphodynamic modules are influenced by accumulated tissue deformation, not just elapsed time.

Conclusions:

  • DynamicAtlas provides a novel framework for high-resolution study of shape formation in living systems.
  • Morphodynamic modules offer insights into the discrete stages of developmental processes.
  • Understanding gene-tissue mechanics interplay is key to deciphering developmental trajectories.