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Clinical Manifestations.

Apurva Mittal1, Kavya K Kumar1, Jyothi M S Gowda1

  • 1National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Multilingualism and language proficiency significantly differ in elderly individuals with and without cognitive impairment. These factors may uniquely influence cognitive functions in those with Mild Cognitive Impairment and Alzheimer's dementia.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Gerontology

Background:

  • Converging evidence suggests multilingualism may enhance cognitive reserve and protect against Alzheimer's dementia (AD).
  • However, findings from existing cross-sectional and longitudinal studies remain inconsistent.
  • This study investigates cognitive performance differences in AD, Mild Cognitive Impairment (MCI), and healthy elders (HE) based on multilingualism (ML) and language proficiency (LP).

Purpose of the Study:

  • To examine cognitive performance variations in HE, MCI, and AD groups.
  • To determine if multilingualism (ML) and language proficiency (LP) impact cognitive performance differently across these groups.
  • To explore the relationship between language background and cognitive health in aging populations.

Main Methods:

  • Utilized data from the NIH/NIA-funded R01 project (1R01AG060610).
  • Assessed ML by the number of languages known (>=3 vs. <3) and LP in speaking, reading, and writing (>=3 vs. <3).
  • Employed multivariate analysis to compare cognitive measures (e.g., delayed recall, design construction, fluency) across diagnostic groups (HE, MCI, AD), controlling for Clinical Dementia Rating (CDR) in MCI and AD.

Main Results:

  • Significant differences in ML and LP were observed across HE, MCI, and AD groups (p<0.05).
  • A trend towards ML effect was noted in MCI (p=0.08), with significant differences in design construction (p=0.004).
  • LP in speaking significantly impacted MCI (p=0.02) and AD (p=0.04) performance in specific cognitive domains like design construction and word list recall.

Conclusions:

  • Multilingualism and proficiency in speaking/reading are significantly associated with cognitive status in the elderly.
  • ML and LP appear to differentially modulate cognitive domains in individuals with MCI and AD.
  • Language background is a crucial factor to consider in the context of cognitive aging and dementia research.