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Clinical Manifestations.

Yiorgos Antoniadis1, Peter S Pressman2, David Arciniegas3

  • 1St. George's University, True Blue, Saint George, Grenada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

Hoarding behavior in neurocognitive conditions is linked to increased chronic pain. Unlike other populations, anxiety and mood symptoms were not significantly correlated in this group.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Gerontology

Background:

  • Hoarding behavior significantly impacts quality of life for patients and caregivers.
  • Previous research suggests links between hoarding and depression, anxiety, and chronic pain.
  • Associations between hoarding and comorbidities are underexplored in neurocognitive conditions.

Purpose of the Study:

  • To investigate the relationship between hoarding behavior and comorbidities in patients with neurocognitive conditions.
  • To explore hoarding behavior's association with pain, anxiety, and mood symptoms in this population.

Main Methods:

  • Administered hoarding screen (SIHS), Neuropsychiatric Inventory Questionnaire (NPIQ), PHQ-9, GAD-7, and PROMIS-10 pain scale.
  • Data collected from caregivers and self-reported by clinic patients with neurocognitive conditions.
  • Correlations between SIHS and other measures were analyzed using mixed effects models.

Main Results:

  • Positive hoarding screens significantly correlated with higher pain ratings (increase of ~3 points, p=0.004).
  • This association persisted after controlling for sex, age, and disease severity.
  • No significant correlations were found between hoarding and anxiety or negative mood symptoms.

Conclusions:

  • Hoarding behaviors are associated with increased pain in patients with neurocognitive conditions.
  • The absence of correlation with mood/anxiety symptoms suggests distinct mechanisms in this population.
  • Further research should explore neurobiological substrates in pain processing and executive function.