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Clinical Manifestations.

Blas Couto1, Alonso Morales-Rivero2, Ignacio Flores3

  • 1Instituto de Neurociencias Cognitivas y Traslacional, INCyT, Buenos Aires, Buenos Aires, Argentina.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

Progressive Supranuclear Palsy (PSP) presents with early motor, cognitive, and behavioral symptoms, often delaying diagnosis. This content highlights subtle early signs to help distinguish PSP from Parkinson

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Area of Science:

  • Neurology
  • Neurodegenerative Diseases

Background:

  • Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterized by motor, cognitive, and behavioral symptoms.
  • Early symptoms include postural instability, falls, diplopia, apathy, impulsivity, and cognitive/language deficits.
  • Diagnostic delays are common due to overlapping symptoms with Parkinson's and Alzheimer's disease.

Purpose of the Study:

  • To identify specific, subtle early clinical features of PSP.
  • To describe the progression of these features during mild-to-moderate stages.
  • To provide methods for distinguishing PSP from Parkinson's and Alzheimer's disease.

Main Methods:

  • Systematic history taking.
  • Time course consideration of symptom development.
  • Physical neuro-examination for characteristic signs.

Main Results:

  • Early detection of subtle clinical features is crucial for timely PSP diagnosis.
  • Understanding symptom progression aids in differentiating PSP from other neurodegenerative conditions.
  • Distinguishing PSP from Parkinson's and Alzheimer's disease is possible with careful clinical evaluation.

Conclusions:

  • Early identification of specific PSP manifestations can reduce diagnostic delays.
  • Systematic evaluation and understanding of disease progression are key to differentiating PSP.
  • Improved diagnostic accuracy facilitates timely referral and management of PSP patients.