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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Neha Singh-Reilly1, Ryota Satoh1, Jonathan Graff-Radford2

  • 1Mayo Clinic, Rochester, MN, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Quantitative susceptibility mapping (QSM) and AV-1451 PET imaging show little evidence of a relationship between susceptibility changes and tau accumulation in atypical Alzheimer's disease (AD). This suggests iron deposition may not be linked to regional tau pathology in AD.

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Area of Science:

  • Neuroimaging
  • Neurodegenerative Diseases
  • Biomarkers

Background:

  • Quantitative susceptibility mapping (QSM) estimates magnetic susceptibility to detect brain iron or myelin changes.
  • Iron co-localizes with neurofibrillary tangles in Alzheimer's disease (AD).
  • Previous QSM studies noted abnormal magnetic susceptibility in atypical AD, but its regional relation to AV-1451 PET uptake is unclear.

Purpose of the Study:

  • To investigate the relationship between quantitative susceptibility mapping (QSM) and AV-1451 PET uptake in patients with atypical Alzheimer's disease (AD).
  • To determine if regional susceptibility changes correlate with regional tau accumulation in atypical AD.

Main Methods:

  • Forty atypical AD patients underwent 3T MRI for QSM and amyloid-β (Aβ) PET, plus 18F-AV-1451 PET scans.
  • Voxel-based regression and region-of-interest (ROI)-based Spearman's correlation analyses assessed QSM and AV-1451 PET relationships.
  • Statistical models were adjusted for age and sex, with corrections for multiple comparisons.

Main Results:

  • Voxel-level analysis revealed positive correlations between AV-1451 PET and QSM only in the left caudate.
  • ROI-level analyses found no significant associations.
  • Uncorrected data suggested potential associations in the occipital lobe and substantia nigra, but these did not survive statistical correction.

Conclusions:

  • Limited evidence suggests regional AV-1451 PET uptake is not strongly related to susceptibility changes in atypical AD.
  • Findings imply that iron deposition may not be associated with regional tau accumulation in AD.
  • Further research is needed to clarify the role of iron in AD pathophysiology.