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Clinical Manifestations.

Fabiana Carla Matos da Cunha Cintra1, Marco Túlio Cintra1, Henrique Dias Furtado De Souza1

  • 1Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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PubMed
Summary
This summary is machine-generated.

Post-COVID Syndrome (PCS) significantly impacts the elderly, causing cognitive and functional decline, frailty, fatigue, and dyspnea. Early identification and treatment are crucial for improving their quality of life.

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Area of Science:

  • Gerontology
  • Infectious Diseases
  • Neurology

Background:

  • Post-COVID Syndrome (PCS) is defined as persistent or new symptoms over 12 weeks post-Sars-CoV-2 infection.
  • Elderly individuals are particularly vulnerable to long-term health consequences following COVID-19.

Purpose of the Study:

  • To identify clinical, cognitive, and functional changes in elderly individuals experiencing Post-COVID Syndrome.
  • To assess the prevalence of specific symptoms and conditions associated with PCS in this demographic.

Main Methods:

  • A cross-sectional study nested within a prospective cohort of elderly individuals diagnosed with COVID-19.
  • Utilized validated scales for cognitive function (DRS), daily activities (ADCS-ADL), PTSD (PCL-C), depression, frailty (IVCF-20), fatigue (FSS), dyspnea (mMRC), and sarcopenia (SARC-F+CC).

Main Results:

  • 80 elderly participants evaluated 10 months post-infection showed high rates of memory difficulties (70.87%), mild cognitive impairment (62.5%), and preserved cognition (22.5%).
  • Prevalence rates included: Frailty (37.50%), Functional Disability (73.33%), Fatigue (46.25%), Dyspnea (88.75%), Sarcopenia (26.25%), PTSD (11.39%), and Depression (11.25%).
  • A significant portion of elderly participants (15%) were diagnosed with dementia.

Conclusions:

  • Post-COVID Syndrome in the elderly is associated with a high prevalence of cognitive and functional disability, frailty, fatigue, and dyspnea.
  • Early and accurate identification of PCS symptoms in older adults is essential for timely intervention.
  • Effective management can prevent long-term complications and enhance the quality of life for elderly individuals affected by PCS.