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Clinical Manifestations.

Juan-Camilo Vargas-González1,2, Ignacio Flores3, Carmela Tartaglia4,5,6

  • 1Memory Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) have a poor prognosis, often leading to significant disability and reduced quality of life within 10 years. Effective communication of prognosis is vital for patient care planning and decision-making.

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Area of Science:

  • Neurodegenerative diseases
  • Tauopathies
  • Neurology

Background:

  • Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are debilitating neurodegenerative disorders.
  • These conditions significantly impact quality of life, with a median survival of less than 10 years post-symptom onset.
  • Patients experience progressive disability, including speech and swallowing difficulties, increasing care burdens.

Purpose of the Study:

  • To equip clinicians with skills for communicating prognosis in PSP and CBS.
  • To promote an assertive and patient-centered approach to discussing disease trajectory.
  • To aid in care planning and support patient/family decision-making.

Main Methods:

  • This session focuses on providing information and practical skills.
  • The approach emphasizes patient-centered communication strategies.
  • Methods involve educating clinicians on discussing prognosis effectively.

Main Results:

  • Clinicians will gain tools to communicate prognosis effectively.
  • Enhanced communication can improve patient and family coping mechanisms.
  • A patient-centered approach facilitates informed life decisions.

Conclusions:

  • Clear communication of prognosis is essential for managing PSP and CBS.
  • Effective prognostic communication supports patients and caregivers.
  • This approach aims to improve the quality of life for individuals with tauopathies.