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Updated: Jan 7, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
Published on: September 7, 2017
DNA Methylation-Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging.
Xueyao Cai1, Weidong Li1, Wenjun Shi1
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
This study reveals that ZDHHC17 gene methylation is linked to facial skin aging. DNA methylation at a specific site influences ZDHHC17 expression, impacting skin aging risk.
Area of Science:
- Genetics
- Dermatology
- Epigenetics
Background:
- Protein palmitoylation is crucial for cellular signaling but its role in skin aging is understudied.
- Epigenetic regulation of palmitoylation genes in dermal aging is not well understood.
Purpose of the Study:
- To investigate the causal links between palmitoylation genes, DNA methylation, and facial skin aging.
- To explore the epigenetic mechanisms underlying age-related dermal changes.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) and summary-data-based MR (SMR) to identify causal genes.
- Performed two-step MR mediation analysis to assess DNA methylation's role.
- Analyzed large-scale GWAS, eQTL, and methylation datasets.
Main Results:
- Identified a significant positive association between ZDHHC17 expression and facial aging risk.
- Confirmed ZDHHC17 transcription's link to facial aging traits.
- Showed DNA methylation at cg23935522 positively regulates ZDHHC17, increasing aging susceptibility by 25.29%.
Conclusions:
- Highlights ZDHHC17 methylation as a potential biomarker for skin aging.
- Suggests ZDHHC17 methylation as a therapeutic target for age-related dermatological conditions.
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