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Successful Treatment of Exploding Head Syndrome With Ketamine
Luiza Harutyunyan1, Mitchell Liester2, Bertrand Liang1,3
1Department of Neurology, St. Joseph's Medical Center, Stockton, USA.
Cureus
|December 25, 2025
Summary
Exploding head syndrome (EHS) treatment is challenging. Sublingual ketamine effectively resolved chronic EHS symptoms in a 75-year-old patient, improving his quality of life.
Area of Science:
- Neurology
- Sleep Medicine
- Pharmacology
Background:
- Exploding head syndrome (EHS) is a parasomnia causing loud head noises and fear during sleep transitions.
- Current EHS treatments are limited due to unknown causes and limited therapeutic options.

