Successful Treatment of Exploding Head Syndrome With Ketamine

Luiza Harutyunyan1, Mitchell Liester2, Bertrand Liang1,3

  • 1Department of Neurology, St. Joseph's Medical Center, Stockton, USA.

Cureus
|December 25, 2025
PubMed
Summary

Exploding head syndrome (EHS) treatment is challenging. Sublingual ketamine effectively resolved chronic EHS symptoms in a 75-year-old patient, improving his quality of life.