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Updated: Jan 7, 2026

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

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Cardiac troponin T elevation predicts mortality in hospitalized COVID-19 patients

Katelyn A Bruno1,2, R Scott Wright3, Joshua Culberson1,2

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States of America.

American Heart Journal Plus : Cardiology Research and Practice
|December 25, 2025
PubMed

Insights

High-sensitivity cardiac troponin T (hs-cTnT) levels predict mortality in hospitalized COVID-19 patients. This prognostic ability holds true for both males and females, irrespective of age.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomarkers

Background:

  • COVID-19 can cause cardiac injury, impacting patient outcomes.
  • Cardiac troponins are key biomarkers for myocardial damage.

Purpose of the Study:

  • To determine if cardiac troponin T (hs-cTnT) levels predict mortality in hospitalized COVID-19 patients.
  • To assess this prognostic ability across diverse demographics including sex and age.

Main Methods:

  • Analysis of hs-cTnT levels in 1050 severely ill COVID-19 patients.
  • Data collected during the first wave of the pandemic (April-August 2020).
  • Inclusion of patients from the Expanded Access Program for convalescent plasma study.

Main Results:

  • A continuous relationship was observed between hs-cTnT levels and mortality.
  • This association was consistent across both male and female patients.
  • The prognostic value of hs-cTnT was independent of patient age.

Conclusions:

  • hs-cTnT is a valuable prognostic biomarker for predicting mortality in hospitalized COVID-19 patients.
  • The predictive capability of hs-cTnT extends across all relevant patient groups.
  • Clinical Trials registration number: NCT04338360.
Abstract

Keywords:
Convalescent plasmaCoronavirus disease 2019High sensitivity troponin

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