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Related Experiment Video

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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jane K Stocks1, Rachel M Keszycki1,2, Daniel Gutstein3

  • 1Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Primary progressive aphasia (PPA) linked to 3R tau pathology shows greater amygdala atrophy than 4R tau pathology. This highlights distinct patterns of brain changes in different tauopathies.

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Area of Science:

  • Neurology
  • Neuroimaging
  • Pathology

Background:

  • Primary progressive aphasia (PPA) is a dementia causing language decline.
  • It can stem from frontotemporal lobar degeneration with tau pathology (FTLD-tau), involving 3R or 4R tau.
  • Amygdala atrophy may contribute to clinical differences in 3R and 4R FTLD-tau.

Purpose of the Study:

  • To investigate amygdala subregion atrophy patterns in 3R and 4R FTLD-tau.
  • To understand the role of the amygdala in the heterogeneity of these tauopathies.

Main Methods:

  • Structural MRI scans from 18 PPA patients (9 with 3R FTLD-tau, 9 with 4R FTLD-tau) and 35 controls.
  • FreeSurfer software was used for amygdala subregion parcellation and normalization.
  • Mixed linear regressions analyzed differences in amygdala subregion volumes.

Main Results:

  • PPA/3R cases showed reduced left amygdala volumes compared to controls in most nuclei.
  • PPA/4R cases had smaller volumes in only the paralaminar and corticoamygdaloid transition areas.
  • PPA/3R cases exhibited greater whole amygdala and specific nuclei atrophy than PPA/4R cases.

Conclusions:

  • Leftward asymmetry of atrophy is evident in PPA.
  • Distinct amygdala subregions are implicated in 3R versus 4R FTLD-tau.
  • Findings suggest amygdala circuit disruptions contribute to differing neuropsychiatric symptoms in FTLD-tau.