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Clinical Manifestations.

Yingzhe Wang1

  • 1Huashan Hospital, Fudan University, Shanghai, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Biological aging clocks for multiple organ systems are crucial for understanding cognitive decline. This study developed brain and body system aging clocks, revealing kidney function

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Area of Science:

  • Gerontology
  • Neuroscience
  • Biomarkers

Background:

  • Biological age is a known metric for aging variance.
  • The aging clocks of cognitive decline across multiple organ systems require further investigation.

Purpose of the Study:

  • To examine composite phenotypic aging.
  • To establish aging clocks for the brain and four body systems.
  • To explore the relationship between organ system aging and cognitive decline.

Main Methods:

  • Utilized brain imaging and physiological phenotypes from the Taizhou Imaging Study and Shanghai Aging Study (N=1448).
  • Analyzed cognitive trajectories over time (low-decline, high-decline, high-stable groups).
  • Developed composite aging clocks for the brain and four body systems.

Main Results:

  • Identified significant associations between kidney function measures (creatinine, homocysteine) and cognitive decline.
  • Demonstrated that renal and metabolic composite phenotypes alter with cognitive function.
  • These composite phenotypes show potential as features for cognitive aging clocks.

Conclusions:

  • The study provides novel insights into heterogeneous phenotypic and organ aging.
  • Findings support the development of comprehensive, personalized strategies for managing cognitive aging.
  • Highlights the role of organ system health in maintaining cognitive function.