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Clinical Manifestations.

Peter S Pressman1,2, Francesca R Dino3, Peter Foltz4

  • 1University of Colorado School of Medicine, Aurora, CO, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Degeneration of dorsal neural pathways in frontotemporal dementia (FTD) leads to greater pitch variation in speech. Ventral pathway degeneration, however, shows less impact on prosodic control.

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Area of Science:

  • Neuroscience
  • Linguistics
  • Neurology

Background:

  • Prosodic deficits in neurodegenerative diseases are often analyzed using a left-right hemispheric framework, focusing on pitch control.
  • Emerging evidence suggests prosodic processing may also follow dorsal-ventral organizational principles linked to different speech signal variation time windows.
  • Pitch variation across conversational speech intervals was explored in individuals with behavioral variant frontotemporal dementia (bvFTD) and semantic variant primary progressive aphasia/semantic behavioral variant FTD (svPPA/sbvFTD).

Purpose of the Study:

  • To investigate pitch variation across conversational speech intervals in neurodegenerative diseases.
  • To explore the role of dorsal and ventral pathways in prosodic control.
  • To differentiate the impact of dorsal versus ventral pathway degeneration on prosodic key shifts.

Main Methods:

  • Ten-minute semi-structured conversations were recorded from 76 participants (31 bvFTD, 16 svPPA, 11 sbvFTD, 18 controls).
  • Uninterrupted speech intervals were manually labeled and analyzed using Praat.
  • Pitch variability was quantified as the standard deviation of median interval pitch, reflecting slower-scale prosodic modulation.

Main Results:

  • A between-group ANOVA showed marginal statistical insignificance (F=2.181, p=0.098).
  • Pre-specified analyses revealed that dorsal pathway disruption (bvFTD) was associated with significantly greater pitch variation compared to ventral pathway disruption (svPPA/sbvFTD) (t=2.351, p=0.022).

Conclusions:

  • Prosodic key across conversational intervals is differentially impacted by dorsal versus ventral pathway degeneration.
  • Results support theories of dorsal-ventral distinctions in speech temporal processing.
  • Findings enhance understanding of how distinct neural pathways regulate prosodic control within different time windows.